Averaging Strategy To Reduce Variability in Target-Decoy Estimates of False Discovery Rate
نویسندگان
چکیده
منابع مشابه
Decoy-free protein-level false discovery rate estimation
MOTIVATION Statistical validation of protein identifications is an important issue in shotgun proteomics. The false discovery rate (FDR) is a powerful statistical tool for evaluating the protein identification result. Several research efforts have been made for FDR estimation at the protein level. However, there are still certain drawbacks in the existing FDR estimation methods based on the tar...
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The target-decoy approach (TDA) has done the field of proteomics a great service by filling in the need to estimate the false discovery rates (FDR) of peptide identifications. While TDA is often viewed as a universal solution to the problem of FDR evaluation, we argue that the time has come to critically re-examine TDA and to acknowledge not only its merits but also its demerits. We demonstrate...
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We provide the first differentially private algorithms for controlling the false discovery rate (FDR) in multiple hypothesis testing, with essentially no loss in power under certain conditions. Our general approach is to adapt a well-known variant of the Benjamini-Hochberg procedure (BHq), making each step differentially private. This destroys the classical proof of FDR control. To prove FDR co...
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MOTIVATION Recent attempts to account for multiple testing in the analysis of microarray data have focused on controlling the false discovery rate (FDR). However, rigorous control of the FDR at a preselected level is often impractical. Consequently, it has been suggested to use the q-value as an estimate of the proportion of false discoveries among a set of significant findings. However, such a...
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Our work on the false discovery rate (FDR), and the paper Benjamini andHochberg (1995), has its origins in two papers concerned with multiple testing ofm hypotheses of which unknownm0 are true. First was Schweder and Spjøtvoll (1982), who suggested plotting the ranked p-values, assessingm0 via an eye-fitted line, and rejecting the otherm−m0 hypotheses. In Hochberg and Benjamini (1990) we develo...
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ژورنال
عنوان ژورنال: Journal of Proteome Research
سال: 2018
ISSN: 1535-3893,1535-3907
DOI: 10.1021/acs.jproteome.8b00802